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Wikipedia - Hyperaldosteronism

Hyperaldosteronism
Classification and external resources

Aldosterone
ICD-10 E26.
ICD-9 255.1
OMIM 103900 605635
DiseasesDB 6187
MedlinePlus 000330
eMedicine radio/354
MeSH D006929

Hyperaldosteronism, also aldosteronism,[1] is a medical condition where too much aldosterone is produced by the adrenal glands, which can lead to lowered levels of potassium in the blood.

Contents

[edit] Types

In endocrinology, the terms primary and secondary are used to describe the abnormality (e.g., elevated aldosterone) in relation to the defect, i.e., the tumor's location.

[edit] Primary (hyporeninemic hyperaldosteronism)

E26.0: Primary aldosteronism was previously thought to be most commonly caused by an adrenal adenoma, termed Conn's syndrome. However, recent studies have shown that bilateral idiopathic adrenal hyperplasia is the cause in up to 70% of cases. Differentiating between the two is important as this determines treatment. Adrenal carcinoma is an extremely rare cause of primary hyperaldosteronism. Two familial forms have been identified: Type I ( dexamethasone supressible ) and Type II ( that has been linked to 7p22.[2] )

Features

Investigations

Management

  • adrenal adenoma: surgery
  • bilateral adrenocortical hyperplasia: aldosterone antagonist e.g. spironolactone

[edit] Secondary (hyperreninemic hyperaldosteronism)

Secondary refers to an abnormality that indirectly results in pathology through a predictable physiologic pathway, i.e., a renin producing tumor leads to increased aldosterone, as the body's aldosterone production is normally regulated by renin levels.

One cause is a juxtaglomerular cell tumor. Another is renal artery stenosis in which the reduced blood supply across the juxtaglomerular apparatus stimulates the production of renin.

[edit] Symptoms

It can be asymptomatic, but the following symptoms can be present

[edit] See also

[edit] Treatment

Treatment includes Spironolactone, a K+ sparing diuretic that works by acting as an aldosterone antagonist.

[edit] References

  1. ^ aldosteronism at Dorland's Medical Dictionary
  2. ^ Lafferty AR, Torpy DJ, Stowasser M, et al. (November 2000). "A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22)". J. Med. Genet. 37 (11): 831–5. PMID 11073536. PMC 1734468. http://jmg.bmj.com/cgi/pmidlookup?view=long&pmid=11073536. 
  3. ^ "Hyperaldosteronism: eMedicine Pediatrics: General Medicine". http://emedicine.medscape.com/article/920713-overview. Retrieved 2009-06-16. 

[edit] External links

Retrieved from "http://en.wikipedia.org/wiki/Hyperaldosteronism"

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Hyperaldosteronism".

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